Abstract
Quantitative structure activity relationship (QSAR) studies on substituted piperidine in the GBR series have been made. Significant correlations were been obtained by multiparametric regression by using structural parameters with indicator parameters. The dopamine transporter (DAT) inhibitory activity of these compounds was found to increase with equalized electronegativity, hydrophobicity and bulk. The generated models were statistically validated using leave one out technique and cross validation methods.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Zenodo (CERN European Organization for Nuclear Research)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
