Abstract
Tuberculosis is a chronic infectious disease which remains one of the leading causes of death worldwide. Scientists are currently engaging both experimental and theoretical methods to seek solution to this deadly disease
Highlights
Tuberculosis (TB) is a chronic infectious disease caused by gram-positive bacteria called Mycobacterium tuberculosis (Mtb)
The ability of drug-like compound to receive electron from nearby compounds explains the role of ELUMO in drug design; N-(4-(3,4difluorophenyl)thiazol-2-yl)-2-(3-nitro-1H-1,2,4-triazol-1yl)acetamide (Compound 6) with -1.61eV is expected to inhibit better than other studied compounds
As reported by Oyewole et al.,[24] unpredictable properties of drug-like molecules may occur as a result of very large dipole moment value; all the studied compounds is expected to have strong non-bonded connections Mycobacterium tuberculosis H37Rv
Summary
Tuberculosis (TB) is a chronic infectious disease caused by gram-positive bacteria called Mycobacterium tuberculosis (Mtb). Mtb frequently attacks the lungs (pulmonary TB) but can harm other part of the body.[1] TB remains one of the leading causes of death worldwide.[2] According to Burel et al, more than 1.2 million TB deaths have been recorded among both young and old globally.[3] Anti-tubercular drugs include isoniazid (INH), rifampicin (RMP), pyrazinamide, ethambutol and streptomycin (SM). Anti-tubercular drugs include isoniazid (INH), rifampicin (RMP), pyrazinamide, ethambutol and streptomycin (SM)
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