Abstract
Introduction: The enzyme caspase-3 plays a critical role in the activation of apoptosis. In cell-free experimental systems, activity of caspase-3 is altered reversibly by variations in [Zn2+]. The oxidant monochloramine (NH2Cl) is produced in inflamed, H. pylori-infested gastric mucosa, at concentrations up to 200μM. Recent studies indicate that exposure of gastric epithelial cells to NH2Cl leads to accumulation of Zn2+ within the cytoplasm. In this study, we explored the effects of NH2Cl on caspase-3 activity within cells of the rabbit gastric gland and tested the hypothesis that oxidant-induced alterations of caspase-3 activity are due, in part, to release of Zn2+ within the cytoplasm.
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