Abstract
Intestinal denervation contributes to enteric motor dysfunction after small bowel transplantation (SBT). Aim: To determine effects of extrinsic denervation on functional motor innervation with the nonadrenergic, noncholinergic (NANC) neurotransmitters vasoactive intestinal polypeptide (VIP) and substance P (Sub P). Hypothesis: Extrinsic denervation by SBT changes the innervation with VIP and Sub P. Methods: 6 groups of rats (n≥6 per group) were studied: naïve controls (NC); 1 wk after anesthesia/sham celiotomy (SC-1); 1 and 8 wk after jejunal and ileal transection/reanastomosis (TA-1, TA-8), or syngeneic (no immune phenomena) orthotopic SBT (SBT-1, SBT-8).
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