Abstract
Introduction: Palladin is a cytoskeletal protein involved in actin organization and cell motility. Recent research showed that a mutation in palladin is linked to a form of familial pancreatic cancer, and that palladin may be overexpressed in sporadic pancreatic cancers. The role of palladin in breast cancer has not been well elucidated. Previous work suggests that palladin expression is increased in phenotypically invasive breast cancer cells, while others report a decrease in palladin mRNA levels in metastatic lesions.
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