Abstract
Increased glucose metabolism is one of the most characteristic phenotypes of malignancy. Rat Intestinal Epithelial (RIE-1) cells that contain an isopropyl-1-thio-β-D-galactopyranoside (IPTG) inducible expression system for H-RasVal-12 was utilized to evaluate phenotypic changes associated with oncogenic Ras expression and cellular transformation. We have demonstrated that oncogenic H-Ras expression increases the committed steps of glucose metabolism, namely glucose uptake and phosphorylation in these cells.
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