Abstract
Introduction: Severe burn causes a pronounced hypermetabolic response characterized by catabolism and extensive protein and amino acid wasting. We recently found that this hypermetabolic state is driven by a severe inflammatory response. In order to study new anti-inflammatory therapeutic approaches, we asked whether rodents, in which new treatments could be tested, have a similar inflammatory response post burn when compared to humans. The aim of the present study was to evaluate the validity of a rat burn model for the characterization in alterations of cytokine expression patterns following severe burn injury during the acute and post-acute inflammatory phases.
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