QOS-2710 YEARS REVIEW OF ENDOCRINOLOGICAL LATE EFFECTS IN SPANISH PATIENTS WITH PRIMARY BRAIN TUMORS IN A TERTIARY HOSPITAL

Abstract

QOS-27. 10 YEARS REVIEW OF ENDOCRINOLOGICAL LATE EFFECTS IN SPANISH PATIENTS WITH PRIMARY BRAIN TUMORS IN A TERTIARY HOSPITAL Miguel Garcia Ariza1, Nancy Portillo Najera2, Usune Gonzalez Camacho1, Raquel Rubio Rojas1, Amaya Vela De Sojo2, Itxaso Rica2, Itziar Astigarraga1, andAuroraNavajas1; PediatricHematologyandOncologyUnit.Department of Pediatrics, Hospital Universitario, Cruces, Bizkaia, Spain; Department of Endocrinology, Hospital Universitario Cruces, Cruces, Bizkaia, Spain OBJECTIVES: Pediatric Central Nervous System (CNS) neoplasms are the most frequent solid tumors in childrenunder 15 years. Since the increase in survival, the patients are in high risk of developing long term sequelae. Considering that the endocrine ones, with awide range of clinical presentation are the second most common after the neurocognitive, we aimed to review our experience from 2005 to 2015. METHODS: An observational retrospective study including 103 pediatric patients was performed. Clinical data were collected both at diagnosis and follow-up, including anthropometric variables, treatment and endocrinological sequelae. SPSS22 was used for statistical analysis. RESULTS: The most frequents anatomical locations were posterior fossa (48%) and midline (35%), and the histological types were astrocytomas (29%), medulloblastoma/PNET (17%) and craniopharyngiomas (7%). Global mortality was 42%. Subgroup of survivors (n 1⁄4 59): The age at diagnosis was 7.6+4.5(vs.5.8+3.6;p 1⁄4 0.036), the complete surgical resection was 67%(vs.29%;p 1⁄4 0.03), and the posterior fossa involvement was 40%(vs.60%;p 1⁄4 0.03). Survival was higher in astrocytomas and craniopharyngiomas. Chemotherapy and radiotherapy were given in 39% and 29%, respectively. Permanent sequelae subgroup (n 1⁄4 17/59): The most frequent endocrine sequel was Panhypopituitarism (56%). The axes involved in descendingorder were: thyroid,GH,ACTH,ADHandFSH/LH.By tumors, craniopharyngiomas 100% presented panhypopitutarism, astrocitomas 10% panhypopituitarism, and medulloblastomas 42% TSH, 28% GH and 14% panhypopituitarism. CONCLUSIONS: In our review, permanent endocrinological deficits were mostly influenced by location and surgery in craniopharyngiomas, and by craniospinal radiotherapy given in medulloblastomas. Neuro-Oncology 18:iii145–iii158, 2016. doi:10.1093/neuonc/now081.27 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.