Abstract
Abstract BACKGROUND Seizures are a common presentation of gliomas that substantially impact morbidity and quality of life. Little is known about the prevalence of seizures among glioma patients in Indonesia. Furthermore, there is no publication regarding clinical characteristics related to this prevalence. OBJECTIVE To measure the prevalence of seizures among glioma patients and its association with tumor grade (low or high), type, and location. METHODS This is a retrospective study based on the medical records of all patients diagnosed with glioma according to histopathology findings. There were 65 patients admitted to the National Cancer Center Dharmais Hospital, Jakarta between January 2019 and December 2020. The demographic characteristics and clinical data were extracted, including clinical and tumor characteristics. Using logistic regression, an odds ratio (OR) with 95% confidence intervals was used to investigate the association between factors related to seizures. RESULTS A total of 65 patients (39 males and 26 females) were included in the study. Most of the patients are ranging from 40 to 49 years old (39%). The prevalence of seizures is relatively high which is 42 out of 65 patients (64.6%). Headache (95%) is the most common complaint in patients. Our study shows that grading and location of tumor were significantly associated with seizure in glioma patients among clinical manifestations (headache, neurological deficits) and pathological classification (p=0.005 and p=0.022). Bivariate analysis using logistic regression showed that low-grade glioma had a 12.2-fold increase in the risk of developing seizures compared to high-grade gliomas with a 95% CI of 1.50 to 99.9 (P< 0.05). Moreover, the temporal location of the tumor had a 5.6-fold increase in the risk of developing seizures compared to the parietal location with a 95% CI of 1.01 to 30.9. CONCLUSIONS Grading and location of the tumor were factors associated with seizures in glioma patients.
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