Abstract
The reaction of the quinoxaline N-oxides (7a, b) with 4,4,4-trifluoroacetoacetate gave the 1,5-dihydro-3-trifluoromethylpyridazino[3,4-b]quinoxaline-4-carboxylates (15a, b), whose oxidation with nitrous acid afforded the 1,4-dihydro-4-hydroxy-3-trifluoromethylpyridazino[3,4-b]quinoxaline-4-carboxylates (16a,b), respectively. The reaction of compounds (16a, b) with 1,8-diazabicyclo[5.4.0]-7-undecene (DBU) provided the 1,5-dihydro-3-trifluoromethylpyridazino[3,4-b]quinoxalin-4-ols (17a, b), whose oxidation with sodium bromate produced the 1-methyl-3-trifluoromethylpyridazino[3,4-b]quinoxalin-4(1H)-ones (6a,b), respectively.
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