Abstract

Objective To evaluate eficaey and safety of qingkailing injecfion for acute cerebral hemorrhage.Methods Randomized controlled trails(RCTs)of qingkailing injec-tion for acute cerebral hemorrhage were identified,eligible studies were included,the outcome we compared included:total efficacy rate,case fatality rate,improvement on neu-rological function loss rate,reduction on haematoma volume and Security.RevMan 5 software and Meta-analysis were used to analyse the data.Results 12 RCTs and 1 197 patients were included,with all trails of low methodological quality.Qingkalling injection VS routine- treatment control,Meta-analysis indicated that(1) the total effective rate of Qingkailing injection is superior to control[RR 1.19,95%CI(1.12,1.26);P<O.O0001];(2) case fatal-ity rate of Qingkailing injection is less than control[RR 0.50,95%CI(0.36,0.69);P<0.0001];(3) Qingkailing injection's effect on improving neurological function loss rate is superior to control[Z=26.28,P<O.O0 001];(4) trails were analysed separately and the results showed that Qingkailing injection is superior to control on reducing the haematoma volume.Conclusion This systematic review showed that qingkailing injecfion is elective for acute cerebral hemorrhage.However the evidence is not strong due to the general low methodological quality.To determinately evaluate eficacy and safety of qingkailing injec-tion for acute cerebral hemorrhage,more rationally designed and strictly executed RCTs with large samples are necessary. Key words: Qingkailing injection; Acute cerebral hemorrhage; Randomized controlled trail; Systematic review; Meta-analysis

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call