Abstract
Cell Biology Several protein quality control processes have been identified that monitor and remove misfolded or damaged proteins in the endoplasmic reticulum. Schmidt et al. asked whether additional pathways monitor proteins further along the secretory pathway in the Golgi complex and the endosome. They identified a degradation pathway in budding yeast cells associated with endosome and Golgi, which they named EGAD. EGAD extracts membrane proteins from the Golgi and endosomes, allowing them to become substrates for cytosolic proteasomal degradation. An important cellular substrate of this pathway is a protein called Orm2, which is involved in down-regulating sphingolipid biosynthesis. The selective degradation of Orm2 facilitates the homeostatic regulation of sphingolipid biosynthesis. EMBO J. 10.15252/embj.2018101433 (2019).
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