代謝症候群患者血漿輔酶Q10、維生素A及維生素E與氧化壓力、抗氧化酵素活性相關性之探討

Abstract

Metabolic syndrome (MS) represents a cluster of physiological and anthropometric abnormalities. The purpose of this study was to investigate the relationships of coenzyme Q10, vitamin A and E, and antioxidant enzymes activities in subjects with MS. Subjects in the case group (n = 72) were according to the criteria for MS, defined by the Taiwan Bureau of Health Promotion, Department of Health (2007). The control group (n = 105) was comprised of healthy individuals with normal blood biochemical values. Plasma coenzyme Q10, vitamin A and E concentrations, lipid profiles, malondialdehyde (MDA) level, and antioxidant enzymes activities [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)] in Red blood cell (RBC) were measured. Subjects with MS had significantly higher concentrations of plasma coenzyme Q10 and vitamin E than those in the control group, but these differences disappeared after normalized for triglyceride level. The ratio of vitamin A to triglyceride and antioxidant enzymes activities were significantly lower in the case group compared with the control group. There was a significantly positive correlations between the levels of coenzyme Q10 and SOD (p < 0.01); vitamin A and GPx (p = 0.05); and vitamin E and GPx (p = 0.04) after adjusting for the potential confounders of MS. Subjects suffering from MS may be under a higher oxidative stress, resulting in low levels of antioxidant enzymes activities and vitamin A. Further studies are needed to evaluate antioxidant vitamins status in patients with long-term chronic MS.