Q-space trajectory imaging for clinical schizophrenia studies

Abstract

Event Abstract Back to Event Q-space trajectory imaging for clinical schizophrenia studies Ofer Pasternak1* 1 Harvard Medical School, Department of Radiology, Bringham and Women's Hospital, United States As q-space trajectory imaging (QTI), and other advanced diffusion encoding schemes, become available, an important question is the feasibility and utility of these schemes for clinical studies. Schizophrenia is one of the main clinical fields in which diffusion imaging provided new ways to identify and understand the disorder. For example, paradigms involving demyelination, neuroinflammation and disconnectivity became substantial following evidence from diffusion imaging studies. In my talk I will review some of the key findings of diffusion imaging in schizophrenia, and will outline the need for more advanced imaging modalities, such as QTI. QTI provides sensitivity to new features, such as eccentricity, however, and perhaps more important for schizophrenia studies, QTI can disentangle several contributions that affect current diffusion measures. These more specific measures provide a stronger link between the identification of group-wise imaging abnormalities, and the understanding of the underlying pathologies, bringing us closer to understanding the etiology and pathophysiology of the disorder. We have implemented QTI on clinical scanners and collected a small pilot dataset from subjects diagnosed with schizophrenia, along with controls. I will present findings from this pilot study, where QTI measures are able to explain changes that are identified in conventional diffusion MRI. I will also present our current sequences that are being used to collect QTI on larger clinical populations. The sequences require less than 15 minutes, similar to advanced DTI measures, demonstrating that QTI sequences can be acquired in clinical feasible times. Keywords: Diffusion, MRI, dMRI, multidimensional, diffusion encoding Conference: New dimensions in diffusion encoding, Fjälkinge, Sweden, 11 Jan - 14 Jan, 2016. Presentation Type: Oral presentation Topic: New Dimensions in Diffusion Encoding Citation: Pasternak O (2016). Q-space trajectory imaging for clinical schizophrenia studies. Front. Phys. Conference Abstract: New dimensions in diffusion encoding. doi: 10.3389/conf.FPHY.2016.01.00002 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 07 Jul 2016; Published Online: 07 Jul 2016. * Correspondence: Prof. Ofer Pasternak, Harvard Medical School, Department of Radiology, Bringham and Women's Hospital, Boston, Massachusetts, MA 02215, United States, ofer@bwh.harvard.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ofer Pasternak Google Ofer Pasternak Google Scholar Ofer Pasternak PubMed Ofer Pasternak Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.