Abstract
In order to elucidate the metabolism of coenzyme Q and vitamin E as the antioxidative agents in the acute vascular accidents, experimental myocardial necrosis induced by isoproterenol injection to rats, was made by the method of Rona. Coenzyme Q9 (Co Q9) and vitamin E (α-tocopherol) in the serum and the lipoprotein fraction were measured. In ordinary state, most of Co Q9 was distributed in VLDL and LDL, and α-tocopherol was in HDL. Co Q9 in VLDL decreased at 6 and 12 hours, most significantly at 12 hours, and in LDL significantly elevated at 12 hours after isoproterenol injection, α-tocopherol in the serum and VLDL showed a rapid decrease, reaching its minimum at 6 hours, and in LDL increased at 12 hours. These results suggest that Co Q9 may locate in the core of VLDL and LDL, and α-tocopherol may predominantly exist in the surface area of the lipoprotein structure.
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