Abstract
Purpose: Numerous studies are indicative of the potent molecular interaction between the energy metabolic supply and different phases of inflammation. Pyruvate is a glycolytic metabolite used for energy production and macromolecule biosynthesis and is also a crucial interaction in multiple metabolic pathways. However, little is known about its effects on cytokine release as well as the molecular events involved. Hence, the current study aims to investigate the role and mechanism of pyruvate in resolving inflammation and to identify its binding partner.
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