Abstract
Frank Merante*1, Teresa Artuso1 and Constanta Badulescu2 Author Affiliations 1Seneca, School of Biological Sciences and Applied Chemistry, Toronto, Ontario, Canada 2The Karate Lab, Toronto Ontario, Canada Received: January 10, 2020 | Published: January 31, 2020 Corresponding author: Frank Merante, Seneca, School of Biological Sciences and Applied Chemistry, Toronto, Ontario, Canada DOI: 10.26717/BJSTR.2020.25.004169
Highlights
Pyruvate, representing the terminal metabolite in glycolysis and the key molecule reacted upon by the pyruvate dehydrogenase complex to initiate the first step of the Kreb cycle (Figure 1), linking anaerobic and aerobic metabolic energy generating pathways, is in relative equilibrium with lactate
We review a non-invasive means of monitoring perturbations to intracellular and blood pyruvate levels indirectly by monitoring alterations of pyruvate in perspiration during the course of physical exertion over an assessed time-period in both a native and supplemented state
We review the potential that pyruvate levels in sweat collected and monitored over an exercise period reflect those present in blood and can be modulated by metabolic intervention using a supplement aimed at improving athletic performance
Summary
Pyruvate, representing the terminal metabolite in glycolysis and the key molecule reacted upon by the pyruvate dehydrogenase complex to initiate the first step of the Kreb cycle (Figure 1), linking anaerobic and aerobic metabolic energy generating pathways, is in relative equilibrium with lactate. We review a non-invasive means of monitoring perturbations to intracellular and blood pyruvate levels indirectly by monitoring alterations of pyruvate in perspiration during the course of physical exertion (i.e., exercise or strenuous activity) over an assessed time-period in both a native and supplemented state. Pyruvate as a biomarker can allow the assessment of exercise performance and recovery, permitting the determination of the effectiveness of metabolic intervention (supplementation) in a non-invasive manner in bodily sweat.
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