Pyrrole analogues of Phencyclidine decrease food and water consumption in mice

Abstract

Various studies have shown that Phencyclidine (1-[1-phenylcyciohexyl] piperidine, PCP, I) and many of its analogues demonstrate pharmacological effects. In this paper effects of some new pyrrole derivatives of, (1-[1-phenylcyclohexyl] pyrrole I, II, and 1-[1-[4-methylphenyl][cyclohexyl]]-pyrrole III) on food and water intake in mice were investigated. Animals were deprived for 24 h before initial of each test for food and water intake evaluation. PCP and its derivatives were injected intraperitoneally (i.p.) and then in 1–12 hour and 30–180 min post-injection, the treated groups were measured for food and water intake, respectfully. The results obtained from the present study show that the pyrrole derivatives of PCP (II and III), decrease food and water intake in the deprived mice dramatically in comparison with the vehicle treated control groups. Our results suggest that the pyrrole derivatives of phencyclidine (II and III) affect those parts of central nervous systems that are involved in feeding behavior.