Abstract
Pyroptosis is a highly specific type of inflammatory programmed cell death that is mediated by Gasdermine (GSDM). It is characterized by inflammasome activation, caspase activation, and cell membrane pore formation. Diabetic cardiomyopathy (DCM) is one of the leading diabetic complications and is a critical cause of fatalities in chronic diabetic patients, it is defined as a clinical condition of abnormal myocardial structure and performance in diabetic patients without other cardiac risk factors, such as hypertension, significant valvular disease, etc. There are no specific drugs in treating DCM despite decades of basic and clinical investigations. Although the relationship between DCM and pyroptosis is not well established yet, current studies provided the impetus for us to clarify the significance of pyroptosis in DCM. In this review, we summarize the recent literature addressing the role of pyroptosis and the inflammasome in the development of DCM and summary the potential use of approaches targeting this pathway which may be future anti-DCM strategies.
Highlights
Diabetes mellitus (DM) is a significant public health issue all over the world (Kim, 2018; Rendra et al, 2019)
Wang Y. et al found that chemical GSDMDrelated pyroptosis of tubular cells in diabetic kidney disease is dependent on the Toll-like receptor 4 (TLR4)/nuclear factorkB (NF-kB) signaling pathway (Wang et al, 2019)
We speculate that pyroptosis can be associated with Diabetic cardiomyopathy (DCM) through the TLR4/NF-kB/nod-like receptor protein-3 (NLRP3) Inflammasome Signaling Pathway, but there are very few scholars studying this pathway in DCM, and future directions can focus on the understanding of this pathway
Summary
Diabetes mellitus (DM) is a significant public health issue all over the world (Kim, 2018; Rendra et al, 2019). Diabetic complications remain the main cause of morbidity and mortality in diabetic patients, with cardiovascular disease being the leading cause of death. Inflammasome was shown to be involved in the pathogenic mechanisms of diabetes and its complications, the potential role and regulatory mechanism of the inflammasome in DCM has remained largely unexplored. Pyroptosis, an emerging type of programmed cell death (Man et al, 2017; Wang et al, 2018a), is associated with the inflammatory response and is activated by bacteria, pathogens, or their endotoxins, leading to the subsequent activation of the caspase family, accompanied by cell swelling, cell membrane pore formation, cell membrane rupture, inflammasome activation, as well as the release of cell contents and inflammatory mediators, resulting in a robust inflammatory response. We attempted to provide new insights for researchers regarding the development of potential therapies for DCM
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
