Abstract
Background The aim of this study was to evaluate effects of pyridoxine and butylated hydroxytoluene (BHT) on lipid peroxidation and on levels of 5-hydroxytryptophan and serotonin. Methods Thirty rats (30 days of age) were used in the survey, measuring levels of lipid peroxidation (TBARS), hemoglobin, 5-hydroxytryptophan (5-HTP), and serotonin (5-HT) after intraperitoneal (i.p.) injections of 4 and 10 mg/kg/day of pyridoxine HCl during 20 days and a single dose of 2 μM/kg (440 μg) of BHT. Results Levels of TBARS and 5-HTP increased considerably ( p <0.05) in all vitamin- and/or BHT-treated groups, and 5-HT increased partially ( p <0.05) only in B 6 with or without BHT-treated groups compared with control group. Conclusions Results suggest that pyridoxine plays a role in tryptophan metabolism, increasing production of 5-HTP.
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