Abstract
Aminoglycosides are very effective against most Gram negative infections, but nephrotoxicity and electrolyte imbalance caused by these compounds pose problems in patients where electrolyte balance needs to be watched closely. The electrolyte imbalance contributes to derangement of the renal functions. This issue has been addressed by changing the dosing schedule and supplementing the patients with these electrolytes. However electrolyte administration and adjusting aminoglycoside doses have their own demerits. In our present study we investigated the effects of Pyridoxal phosphate on electrolyte balance when given in combination with aminoglycosides. Our findings suggest that Pyridoxal phosphate prevents aminoglycoside induced electrolyte imbalance, a finding which has not been reported previously. These results should be considered as an important input regarding prevention of aminoglycoside induced decrease in electrolyte levels. Further studies will help healthcare providers to manage patients more efficiently, in whom electrolytes balance may need to be observed.
Highlights
Many of the Gram-negative infections have resurfaced which revived the interest of physicians in the use of aminoglycosides
Dose dependent bactericidal effect and postantibiotic effect make aminoglycosides a good candidate for once-daily dosing in patients with normal renal function and since the dosing intervals are longer, toxicity may be reduced [4,5]
In our present study we investigated the effects of Pyridoxal phosphate on potassium and calcium serum levels when given in combination with Gentamycin and our findings suggest that Pyridoxal phosphate prevents Gentamycin induced electrolyte imbalance
Summary
Many of the Gram-negative infections have resurfaced which revived the interest of physicians in the use of aminoglycosides. This has brought back to light the issues related to these drugs i.e. the spectrum of antimicrobial susceptibility and their toxicity [1]. Antimicrobial effect of aminoglycosides is concentration dependent and increases with increasing concentrations of the antibiotic [2]. Dose dependent bactericidal effect and postantibiotic effect make aminoglycosides a good candidate for once-daily dosing in patients with normal renal function and since the dosing intervals are longer, toxicity may be reduced [4,5]. Albeit once-daily regimen has improved the state of affairs over what prevailed thirty years ago, the safety of aminoglycosides remains a controversial issue as far as renal tissue is concerned [7,8]
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