Abstract
Pyridinium hydrobromide perbromide (PHPB) has been extensively used in organic synthesis as a selective brominating reagent for alkenes, [¹-5] alkanes, [6] arenes, [7] ketones, [7] [8] anilines, [9] aromatic ethers, [¹0] N-heterocycles, [¹¹] and oxidizing reagents. [¹²] [¹³] PHPB forms red prismatic crystals and its melting point is at 134 ˚C. Further, it is easy to handle, stable and environmentally safe. [¹4] PHPB has been used for regioselective heterocyclization of ortho-cyclohexenyl phenols [¹5] and ipsobromodeformylation in o-hydroxy and o-methoxy substituted aromatic aldehydes. [¹6] It was also found to be a useful catalyst for the chemoselective deprotection of primary TBS and TES ethers, [¹7] hydrolysis of thioacetals, [¹8] and hydroamination of activated styrenes. [¹9]
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