Pyridine-mediated efficient synthesis of (benzo)thiazoles-containing amides via the acylation of 2‐amino(benzo)thiazoles under ultrasonic irradiation

Abstract

An efficient and practical methodology for the synthesis of (benzo)thiazoles-containing amides through pyridine-mediated acylation of 2‐amino(benzo)thiazoles under ultrasonic irradiation was developed. The short reaction time (within 1 min), good functional group tolerance, experimental simplicity and ease of scale-up were salient features of the present strategy, which enables straightforward access to the expected products with good to excellent yields. Additionally, further transformations of the resulting amides were also studied.