Abstract
In this study, three novel mononuclear M(II)-pyridine-2,5-dicarboxylate (M = Co(II), Cu(II), and Zn(II)) complexes with pyridine-2,5-dicarboxylic acid or (isocinchomeronic acid, H2pydc) and 2,2′-bipyridine (bipy), [Co(pydc)(bipy)2]·5H2O (1), [Cu(pydc)(bipy)2]·6H2O (3), and [Zn(pydc)(bipy)2]·6H2O (4) have been synthesized. Elemental, thermal, and mass analysis; magnetic susceptibilities; molar conductance; IR and UV/vis spectroscopic studies have been performed to characterize the complexes. Subsequently, the results of antimicrobial activity of the two ligands H2pydc and bipy, and the four compounds (1), (2), (3), and (4) were obtained by the agar disk diffusion method. Furthermore, the cytotoxic activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide viability assay for 24 and 48 h on rat glioma cells (C6).
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