Abstract

5-Alkynylpyridazin-3(2 H)-ones or 5-(2-chloroalkenyl)pyridazin-3(2 H)-ones were isolated during the cleavage of the methoxymethyl group in a series of 5-alkynyl-2-methoxymethylpyridazin-3(2 H)-ones by treatment with hydrochloric acid. The efficient and selective cleavage of the methoxymethyl group in these compounds can be performed under mild conditions by employing aluminium chloride.

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