Abstract

In the present study we investigated the behavior of 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbonitrile towards the hydrazine hydrate which gives 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboximidohydrazide which in turn was subjected to subsequent reactions with benzaldehyde, acetic anhydride, acetyl acetone, formic acid, maleic anhydride and phthalic anhydride. The new synthesized compounds were confirmed by their infrared, mass spectrum, 1H-NMR, and elemental analyses, and further screened for antimicrobial activity. Several compounds showed moderate to low activity against the examined micro-organisms.

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