Abstract
Long-lasting insecticide nets (LLINs) have had a large role in the reduction of malaria incidence in the endemic countries in sub-Saharan Africa. However, pyrethroid resistance is now widespread and threatens to not only render LLINs irrelevant, but also to reverse the gains made towards malaria elimination. The concern about resistance has prompted a suggestion that insecticides should be removed from LLINs to preserve them for other use in vector control measures. 1 Paaijmans KP Huijben S Taking the ‘I’ out of LLINs: using insecticides in vector control tools other than long-lasting nets to fight malaria. Malar J. 2020; 19: 73 Crossref PubMed Scopus (5) Google Scholar Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaignIn Uganda, where pyrethroid resistance is high, PBO LLINs reduced parasite prevalence more effectively than did conventional LLINs for up to 18 months. This study provides evidence needed to support WHO's final recommendation on use of PBO LLINs. Full-Text PDF Open Access
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