Abstract
AbstractPyrazolopyrimidine scaffold is one of the most favored heterocycles in drug discovery. Herein, a convenient and efficient protocol for the assembly of the hitherto unreported 4‐(4‐(dimethylamino)phenyl)‐3‐methyl‐4,5‐dihydro‐1H‐pyrazolo[3,4‐d]pyrimidine‐6‐thiol (1) was disclosed. This approach comprises arylidene formation via a Knoevenagel condensation reaction between commercially available 3‐methyl‐1H‐pyrazol‐5(4H)‐one and 4‐(dimethylamino) benzaldehyde followed by a subsequent cyclization reaction with thiourea. Thereafter, a series of assorted fused and attached heterocycles originating from pyrazolo[3,4‐d]pyrimidine derivative 1 was synthesized. Finally, the antibacterial activity of the novel assembled heterocycles was in vitro evaluated against diversified Gram‐negative and Gram‐positive bacteria. Various analytical and spectroscopic methods were utilized to confirm the proposed structures of the newly‐synthesized compounds.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.