Pyrazole treatment of rats potentiates CCl 4-but not CHCl 3-hepatotoxicity

Abstract

Rats were treated with pyrazole to increase the liver content of the “alcohol-inducible” form of cytochrome P-450. This treatment increased the sensitivity of these animals to CCl 4-hepatotoxicity assessed by increases in SGPT and SGOT levels and decreases in microsomal cytochrome P-450 and aniline p-hydroxylase activity. However, the hepatotoxicity of CHCl 3 was not increased by pyrazole-treatment. These data are consistent with the hypothesis that the “alcohol-inducible” form of cytochrome P-450 is capable of CCl 4- but not CHCl 3-activation.