Abstract
Pyrazole-carboxaldehydes as versatile precursors for different pyrazole-substituted heterocyclic systems
Highlights
Heterocycles are significant classes of compounds that make up more than half of all known organic compounds. They exist in a wide range of medications, most supplements, many natural products, and biomolecules like hormones, antibiotics, alkaloids, vitamins, etc
Many heterocyclic compounds were found to exhibit a wide variety of biological activities including antitumor, antibiotics, anti-inflammatory, antidepressant, antimalarial, anti-HIV, antimicrobial, antibacterial, antiviral, antidiabetic, herbicide, and fungicide agents
Fekri et al.102 reported that the one-pot multi-component reaction of 4-pyrazole-carboxaldehyde 2, ethyl pyruvate 39, and bromine gave 2,3-dihydrofuranediones 40 under ultrasonic irradiation (Scheme 19)
Summary
Heterocycles are significant classes of compounds that make up more than half of all known organic compounds. Nitrogen-containing heterocycles are among the most active compounds due to their large occurrence in natural products They are among the core structures of various biologically active compounds and are considered as essential roles in many of the chemical reactions occurring in all organisms.. Some of the pyrazole derivatives have important applications as brightening agents and some exhibit significant solvatochromic and electroluminescence properties.31 Their application in material chemistry, semiconductors, liquid crystals, and organic light-emitting diodes have been extensively reported. The diversity in the numerous potential applications of pyrazoles encouraged the continuous investigation of this class of compounds and prompted authors to search for more effective and selective synthetic routes to this type of compounds and allowing the production of a large number of structurally diverse derivatives with various biological profiles. Based on the size of the heterocyclic ring as well as the position and number of the heteroatoms, heterocyclic compounds mentioned in this review are arranged
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