Abstract
PXR interaction with p53: a meeting of two masters.
Highlights
Zhou et al.[7] demonstrated the antiapoptotic role of pregnane X receptor (PXR) in human colon cancer cells, providing a potential mechanistic connection between xenobiotic metabolism and apoptotic signaling
Gotoh and Negishi[14] recently characterized the novel statin/PXR/serum/glucocorticoid regulated kinase 2 (SGK2)-mediated signaling pathway that occurs in hepatic gluconeogenesis
They reported that PXR acts as a scaffold for phosphatase 2C and SGK2 to induce dephosphorylation of SGK2, thereby promoting PXRmediated activation of gluconeogenic genes in human liver cells and enhancing gluconeogenesis
Summary
Zhou et al.[7] demonstrated the antiapoptotic role of PXR in human colon cancer cells, providing a potential mechanistic connection between xenobiotic metabolism and apoptotic signaling. Tel: +901 595 5937; Fax: +901 595 5715; E-mail: Taosheng.chen@stjude.org The master regulators PXR and p53 appear to have important yet opposing roles in the cellular response of tumor cells to chemotherapy.
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