Abstract
IntroductionPortal hypertensive enteropathy (PHE) remains difficult to diagnose in patients with cirrhosis and portal hypertension. Limited test choices exist for the inspection of the small bowel in these patients. Small...
Highlights
Portal hypertensive enteropathy (PHE) remains difficult to diagnose in patients with cirrhosis and portal hypertension
Mucosal-Associated Invariant T (MAIT) cells are characterised by expression of the semi-invariant TCR a-chain Va7.2Ja33 and high expression of CD161 and shown to play a role at mucosal barriers
Very little is known about the phenotype and functions of liver infiltrating MAIT cells
Summary
Mucosal-Associated Invariant T (MAIT) cells are characterised by expression of the semi-invariant TCR a-chain Va7.2Ja33 and high expression of CD161 and shown to play a role at mucosal barriers. They display a limited T cell receptor repertoire being restricted by the MHC class 1-related molecule, MR1 but secrete high levels of pro-inflammatory cytokines suggesting they may play an important role in liver inflammation. Very little is known about the phenotype and functions of liver infiltrating MAIT cells. In this study we investigated the frequencies and phenotypes of human liver infiltrating MAIT cells in healthy donors and diseased livers
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
