PWE-171 Bone Morphogenetic Protein (BMP) Pathway Dysregulation Subverts Oncogene Induced Senescence Mechanisms in the Serrated Pathway of Tumourigenesis

Abstract

IntroductionThe serrated colorectal carcinogenesis pathway is increasingly recognised as a distinct and important route to CpG island methylated phenotype (CIMP) carcinomas, yet comparatively little is known about the molecular pathogenesis...