Abstract
Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder affecting mainly Jews, Armenians, Turks and Arabs. Recently, several pro- and anti-inflammatory cytokines have been studied in sera of Armenian and Turkish FMF patients during and in between crises. However, the information were limited and contradictory.
Highlights
Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder affecting mainly Jews, Armenians, Turks and Arabs
Ex vivo cytokine profile The levels of pro-inflammatory cytokines IL-6 and TNF-a were higher in unstimulated and LPS stimulated PBMC supernatants of FMF patients in crises compared to the control group
There was no difference in spontaneous IL1-b and IL-1 a release by PBMCs of FMF patients and controls
Summary
Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder affecting mainly Jews, Armenians, Turks and Arabs.
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