Abstract
Research in drug release field, nowadays, focuses on more efficient systems for better release of the drug and wider timespan of action, granting several benefits to the patient’s organism and to the industry. The present work aims on developing a matrix of polymer nanocomposite based on Polyvinylpyrrolidone (PVP), bentonite clay and two different vanadium oxides, via spray drying technique. The goal is to achieve a long and steady release of metformin hydrochloride in future formulations with this drug. Since either the nanocomposites or metformin hydrochloride is highly hydrophilic, it is most suited for a future formulation of tablets. For now, the nanocomposites obtained were characterized through Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Thermogravimetric Analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR). The SEM and XRD analysis portrayed a very amorphous and homogenized material. TGA and FTIR proved the insertion of the nanoparticles, thus granting to the new material a slightly higher thermal resistance. The NMR analysis, using T1H parameters, is key for determining the formulations would behave better for extending the resistance of the nanocomposite’s matrix with the drug in later dissolution of tablets.
Highlights
Nanostructured materials are part of a class of hybrid materials [1] that have characteristics that differentiate them from the composites due mainly to the greater aspect ratio that the nanometric particles have, providing a greater surface area
The nanocomposites obtained were characterized through Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Thermogravimetric Analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR)
Thermogravimetric analysis showed that the nanocomposites in all the formulations presented similar resistance to thermal degradation among the different samples
Summary
Nanostructured materials are part of a class of hybrid materials [1] that have characteristics that differentiate them from the composites due mainly to the greater aspect ratio that the nanometric particles have, providing a greater surface area. Due to the easy availability, there are better adjustment of the doses administered, better acceptance by patients and cost-efficient production, among other reasons [7] [8] [9] [10] [11] Among these systems, especially those that do controlled diffusion and dissolution, those of hydrophilic matrices stand out. Some important characteristics of these matrices include the fact that they are of simple formulation, of easy and inexpensive production, besides their excellent in vitro-in vivo correlation Another important feature and advantage is the possibility of associating high molecular weight hydrophilic drugs with hydrophilic polymer matrices, which are the most widely used controlled release systems in a few years more recently [12] [13] [14] [15]. In order to overcome the hydrophilic polymer barrier and to make the drug more soluble in the solvent, it is possible to use molecular engineering in the nanocomposite formulation, so that the availability of the drug is greater, compensating for its naturally low solubility [10] [15] [16] [17] [18]
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