Abstract
Herein, thermo-responsive nanocontainers depended on mesoporous silica nanoparticles (MSN) functionalized with two copolymers: poly(3-methacryloxypropyltrimethoxysilane) “PMPS, source of condensation with silica” and poly(N-vinylcaprolactam) “PVCL” were synthesized by a facile one-step approach, characterized then evaluated as antifungal materials. Taking advantage of the polymer gatekeeper strategy, the loading or release processes of anidulafungin (AFG) as a model antifungal drug were adjusted by the stimuli-responsiveness of PVCL. Upon temperature treatment at various conditions, the loaded AFG was released with a killing effect against four strains of fungi, as reported by filter-paper and hole-plate technique. This kind of stimuli-sensitive nanocontainers can be a potential platform for biomedical applications.
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