Abstract
The construction and general performance characteristics of two novelpotentiometric membrane sensors responsive to the acebutolol are described. Thesensors are based on the use of ion-association complexes of acebutolol (AC) withtetraphenylborate(TPB) (I) and phosphomolybdate(PM) (II) as exchange sites in a PVCmatrix. The sensors show a fast, stable and near- Nernstian for the mono charge cationof AC over the concentration range 1×10-3 - ~10-6 M at 25 °C over the pH range 2.0 -6.0 with cationic slope of 51.5 ± 0.5 and 53.0 ± 0.5 per concentration decade for AC-Iand AC-II sensors respectively. The lower detection limit is 6×10-6 M and 4×0-6 M withthe response time 20-30 s in the same order of both sensors. Selectivity coefficients ofAC related to a number of interfering cation and some organic compounds wereinvestigated. There are negligible interferences are caused by most of the investigatedspecies. The direct determination of 3 - 370 μg/ml of AC shows an average recovery of 99.4 and 99.5% and a mean relative standard deviation of 1 . 5 % at 100.0 μg/ml forsensor I and II respectively. The results obtained by determination of AC in tablets usingthe proposed sensors which comparable favorably with those obtained by the Britishpharmacopoeia method. In the present investigation the electrodes have been utilized asend point indicator for some precipitation titration reactions.
Highlights
Acebutolol hydrochloride, (Fig.1.) is a cardioselective, hydrophilic β-adrenoreceptor blocking agent with mild intrinsic sympathomimetric activity for use in treating patients with hypertension and ventricular arrhythmias
Potentiometric membrane sensors have been more extensively used in pharmaceutical analysis
AC readily reacts with NaTPB and phosphomolybdic acid (PMA) solution to form a sparingly soluble ion associate complex of 1:1 and 3:1 for AC: TPB and AC: PM respectively
Summary
Acebutolol hydrochloride, (Fig.1.) is a cardioselective, hydrophilic β-adrenoreceptor blocking agent with mild intrinsic sympathomimetric activity for use in treating patients with hypertension and ventricular arrhythmias. N H existing publications concerning the individual determination of AC in pharmaceutical preparations were based on, spectrophotometry [7,8,9,10], spectrofluorimetry [8], thin layer chromatography (TLC)[9], polarography [11], HPLC [9,10,12], GC[10] and CE[13] Since, some of these methods required expensive equipment(s) and/or especial treatment. The only reported method is a coated wire electrode for some β-blocker and calcium blocker has been suggested based on the use of dinonylnaphthaline sulphonic acid as ion exchanger material Their selectivity behavior was accurately predicted from calculated distribution coefficient constant for each drug [18] (acebutolol one of them).
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