Abstract
There is dispute about the validity of the nitrogen rebreathing technique for determination of Pv̄ O 2 . This theoretical analysis examines the circumstances under which the technique is likely to be applicable. When the plateau method is used the probable error in Pv̄ O 2 is ±2.5 mm Hg at rest, and of the order of ±1 mm Hg during exercise. Provided the rebreathing bag size is reasonably chosen, Denison's extrapolation technique gives results at least as accurate as those obtained by the plateau method. At rest, however, extrapolation should be to 30 rather than to 20 sec.
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