Abstract
In silico searches of promoter sequence motifs, combined with analysis of microarray data, have revealed potential synergistic interactions within the yeast transcriptional regulatory network
Highlights
Some transcription factors display greater-than-additive effects when they interact with each other and the transcriptional machinery at a promoter - a phenomenon known as transcriptional synergy
To assess the impact of each motif, or motif combination, on gene expression, they estimated the overall similarity of the expression profiles of all the genes containing that motif, in different physiological conditions
A pair of motifs was operationally considered as 'synergistic' if the expression coherence score of genes containing both motifs in their promoters was significantly greater than that of genes containing either motif alone
Summary
Some transcription factors display greater-than-additive effects when they interact with each other and the transcriptional machinery at a promoter - a phenomenon known as transcriptional synergy. Pilpel et al first established a database of known and putative regulatory motifs (329 motifs, including 37 known) and identified (using ScanACE12) the yeast promoters containing each motif. To assess the impact of each motif, or motif combination, on gene expression, they estimated the overall similarity of the expression profiles of all the genes containing that motif, in different physiological conditions (the expression coherence score).
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