Putative Role of MCT1 rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus.

Xavier Ramírez De La Piscina-Viúdez,Arkaitz Castañeda-Babarro,Ildus I Ahmetov,Diego A Bonilla,Alex Martínez-Ascensión,Julen Díaz-Ramírez,Jesús Álvarez-Herms,Adrián Odriozola-Martínez,Jon Larruskain,Richard B Kreider

doi:10.3390/sports9100143

Abstract

Monocarboxylate transporters (MCTs) have been proposed as important mediators of the exchange between lactate (La−) producer and La− recipient (consumer) cells. Previous studies have suggested that the MCT1 A1470T genotype could be related to different physical performance phenotypes. This study followed the guidelines for Strengthening the Reporting of Genetic Association Studies (STREGA) and aimed to evaluate the distribution of the MCT1 polymorphism rs1049434 in endurance-trained athletes compared to the untrained population. Moreover, this study explored the potential influence of the polymorphism alleles phenotypes on high-intensity exercise performance. In a cross-sectional study fashion, a total of 85 triathletes from northern Spain were genotyped for MCT1 rs1049434 and compared to a control group of 107 healthy male participants (1000 Genomes Research Study for Iberian Populations in Spain). All athletes performed a 30 s Wingate all-out test (WAnT) on a cycle ergometer. Peak and mean power (absolute and relative) were measured. After verification of the Hardy–Weinberg equilibrium, the findings indicated that the MCT1 TT genotype was overrepresented in triathletes in comparison to the genotypic frequency of the general Spanish population. No significant associations were found between any MCT1 genotype and peak or mean power performance in the WAnT. Further studies are required to understand the relationship among MCT1 A1470T polymorphism, endurance-trained athletes, and high-intensity performance.

Highlights

Lactate (La− ) is undoubtedly one of the most studied metabolic markers measured in health, disease, and exercise sciences [1]
We evaluated and analyzed the results obtained from 85 endurance-trained males
TT genotype was response overrepresented in enregarding interindividual physiological molecular allostatic is limited; one durance-trained athletes compared to the general population could hypothesize that the TT genotype might be overrepresented in endurance athletes

Summary

Introduction

Lactate (La− ) is undoubtedly one of the most studied metabolic markers measured in health, disease, and exercise sciences [1]. High-intensity exercise is characterized by the predominance of extramitochondrial pathways of energy production (i.e., phosphagen system and glycolysis), which drive the subsequent production and accumulation of hydrogen ions (H+ ), with the associated decrease in pH within fast-twitch muscle fibers [5]. It is this accumulation of H+ and other metabolites (Pi and poor Ca2+ handling) in the active skeletal muscle, and not the La− concentration per se, which is linked to the acute reduction in force and power (muscle fatigue) [6,7]. Due to the high energy requirements of the working muscle during physical exercise, a family of proton-linked symporters called monocarboxylate transporters (MCTs, known as the SLC16A family) has been proposed as an important mediator of the exchange between La−

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