Abstract
We examined the distribution of several extracellular matrix molecules (ECM) and their relationship to regenerating axons in embryonic day 14 spinal cord transplants 1 to 12 weeks after transplantation into adult rats. We used immunocytochemical tech niques to label chondroitin sulfate proteoglycans (CSPGs) and tenascin-C in adjacent sections. Synthesis of these molecules by astrocytes is thought to be one mechanism by which astrocytes inhibit regeneration in the central nervous system (CNS); glial fibrillary acidic protein antibody was used to label astrocytes and examine their rela tionship to both the ECM molecules and regenerating calcitonin gene-related pep tide (CORP)-contammg dorsal roots. We also compared the expression and distribu tion of these five markers in transplants with normal spinal cord development.
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