Abstract
To study the exact effect of purple wheat (PW) on dyslipidaemia in rats so as to lay the foundation of a dietary therapy for hyperlipidaemia. A total of 42 rats were randomly divided into two groups: normal control group (NC) consisting of 12 rats were fed with standard diet in the whole testing process, the other group rats were fed with high-fat diet to induce dyslipidaemia. The dyslipidaemic rats were averagely divided into three groups: dyslipidaemia control group (DC) with 60% common wheat flour, PW1 group with diet containing 60% purple wheat Jizimai1 flour, PW3 group with 60% purple wheat Jizimai3 flour. Six weeks later, the weight-gain-ratio of the rats in PW1 and PW3 groups were lower as compared to the rats in DC and NC groups. Further, we found that the levels of triglyceride, total cholesterol and low-density lipoprotein in the PW1 and PW3 groups were significantly reduced to almost that of normal levels. Finally, the results of hematoxylin and eosin staining showed that intaking of Jizimai1 and Jizimai3 could repair hepatocyte steatosis and kidney injury due to dyslipidaemia. Purple wheat diet therapy reduced lipid metabolism disorders and the liver tissue and renal injury in hyperlipidaemic rats.
Highlights
Cardiovascular and cerebrovascular diseases are a major threat to human health
It was observed that the body weight of rats continuously increased up to six weeks; normal control group (NC) group rats had the highest body weight, followed by dyslipidaemia control group (DC) and purple wheat 1 (PW1) group rats, and purple wheat 3 (PW3) group rats had the lowest weight
We observed that the weight-gain-ratio of the PW1 and PW3 group rats was significantly lower than that of the DC group and the NC group rats (Figure 2), which was in agreement with previous reports (Liu, 2017)
Summary
Cardiovascular and cerebrovascular diseases are a major threat to human health. Hyperlipidaemia is a potential and independent risk factor (De Moura et al, 2009; Hong et al, 2012; Navar-Boggan et al, 2015) for various cardiovascular and cerebrovascular diseases including atherosclerosis and coronary heart disease. A study (Zhang et al, 2016) concluded that dietary fibre composed of wheat, corn, grains and beans can significantly reduce the levels of triglyceride (TG), total cholesterol (TC) and low-density lipoprotein (LDL) in hyperlipidaemic rats. The most recent report (Liu, 2017) that black whole wheat flour can significantly reduce serum levels of TC, TG and LDL, and increase serum levels of the high-density lipoprotein (HDL) in hyperlipidaemic rats. These findings suggest that purple wheat can alleviate lipid metabolism disorders. R. China 2 Institute of Cash Crops – ICC, Hebei Academy of Agriculture and Forestry Sciences – HAAFS, Hebei Province, P. Yaning Meng and Suque Lan contributed to the study
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