Purple Thrombocytopenic Thrombotic

Abstract

Thrombotic thrombocytopenic purpura is a rare disease of immune origin, belonging to thrombotic microangiopathies. In most cases, it can present as microangiopathic hemolytic anemia accompanied by thrombocytopenia, neurological deficit and kidney abnormalities. The present clinical case belongs to a female patient with no significant personal or family history, who went to the doctor for a clinical picture of 2 days of evolution with hematuria, general malaise, asthenia and adynamia, on physical examination without alterations, with vital signs in ranges of normality. The diagnosis of thrombotic thrombocytopenic purpura was made due to hemolysis, elevated levels of lactate dehydrogenase and a reduction in serum haptoglobin accompanied by the presence of serum schistocytes> 6% in the peripheral blood smear. Thrombocytopenic purpura is a diagnostic challenge because its clinical picture is often nonspecific, making it more difficult to start its treatment in a timely manner. Another drawback is the high costs for ADAMTS13 activity tests. Despite the fact that the treatments for this disease have low success rates, in our clinical case our patient responded favorably to the treatment instituted