Abstract
As an idea to ensure the success of OMICS research, there is Virchow's pathological ideas of physical disease. This idea is that one cell, a group of cells, a substance, and a group of substances are specific for each disease. Based on this idea, it can be inferred that the unity and purity of the sample and the disease used are extremely important factors. In this study, the aim is to show how the difference in trivial centrifugal conditions of whole blood affected the plasma concentration of Phosphoethanolamine (PEA), a biomarker of depression shown in our previous study, It turned out that the value of PEA increases when the rotor is a swing type, or when the temperature at the time of centrifugation is set at 4°C. This increase might be due to platelet contamination in isolated plasma. Therefore, especially when the researchers are looking to discover an unknown marker, special attention should be paid to sample.
Highlights
Thanks to Virchow's cellular principle [1], we were able to show that Major Depressive Disorder (MDD) with low plasma Phosphoethanolamine (PEA) concentration [2] is a central feature of MDD [3] and appears as a main group of MDD with psychomotor retardation and cognitive impairment [4].If psychiatric disorders were physical diseases, it would have been reasonable to search for biomarkers by OMICS technologies
Possible adverse effects of platelets remaining in plasma on for OMICS research
Structures capable of forming PEA gradient of PEA are considered lymphocytes and others, but we assume that platelets are most dubious as discussed in this study
Summary
If psychiatric disorders were physical diseases, it would have been reasonable to search for biomarkers by OMICS technologies. Recent Treatment Guidelines of Depression [6] have been created on the premise that there is little doubt about the effectiveness of antidepressants in moderate or severe depression [7,8]. This means that several forms of depression can be considered as disease of the brain like various specific physical organ diseases. It would be reasonably and beneficial to hypothesize a bulk of psychiatric disorders as physical diseases
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