Abstract
Purinergic Signaling in Bone
Highlights
Recent work has shown that the P2X7 receptor is important in bone-related conditions, osteoporosis
Purinergic signalling has been associated in the pathophysiology of several bone and cartilage diseases, including osteoarthritis, rheumatoid arthritis, and osteoporosis and might be implicated in the deleterious skeletal effects of cancer and on bone pain
These research papers highlight the importance of genetic background when looking at the functional effects of the P2X7 receptor and suggest that when mouse models are used to test the efficacy of P2X7 receptor agonists and antagonists it is taken into account
Summary
Recent work has shown that the P2X7 receptor is important in bone-related conditions, osteoporosis. It has become apparent that extracellular nucleotides, signalling via P2 receptors, play an important role in the regulation of bone turnover. Purinergic signalling has been associated in the pathophysiology of several bone and cartilage diseases, including osteoarthritis, rheumatoid arthritis, and osteoporosis and might be implicated in the deleterious skeletal effects of cancer and on bone pain.
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