Abstract
ATP actions on central inspiratory networks are determined by a 3-part signaling system comprising: i) the excitatory actions of ATP at P2 receptors (Rs) ii) ectonucleotidases that degrade ATP into adenosine (ADO), and iii) the inhibitory actions of ADO at P1Rs. During hypoxia, an initial increase in ventilation is followed by a secondary depression that is life threatening in premature infants. The release of ATP in respiratory networks, including the preBötzinger Complex (preBötC, important site of inspiratory rhythm generation) attenuates this secondary ventilatory depression.
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