Abstract
Many authors have studied enzymes of the purine metabolism in relation to subtypes of acute lymphoblastic leukemia leukemia (ALL). Recently we found that low activities of adenosine deaminase (ADA), purine nucleoside Phosphorylase (PNP) and hypoxantine-guanine phosphoribosyltransferase (HGPRT) correlated with a poorer prognosis in childhood ALL.1, 2 A small subset of children with a very high ecto-5’nucleotidase (ecto-5’NT) expression on their leukemic cells also had a relatively poorer prognosis.3, 4 The hypothesis that the prognostic value of these enzymes could be explained by a relation with thiopurine resistance was not confirmed.1, 2, 4 KeywordsAdenosine DeaminaseChildhood LeukemiaPurine Nucleoside PhosphorylaseNucleotidase ActivityNormal Hematopoietic CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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