Abstract
The association of deficiencies of purine metabolic enzymes with immunodeficiency diseases has stimulated research in purine metabolism of lymphoid cells. Up to now our knowledge about purine metabolism of other cells of the immune system, e.g., macrophages, is relatively limited. During phagocytosis, macrophages excrete large amounts of uric acid1. The excretion of uric acid suggests that nucleotide catabolism may be predominant in phagocytosing macrophages. On the other hand, purine bases and nucleosides formed during digestion of nucleic acids may be transported across the phagolysosomal membrane and reutilized into intracellular nucleotide pools. Indeed activities of several purine salvage enzymes along with enzymes of purine catabolism have been found in macrophage extracts1,2.
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