Abstract
Summary Effects of the abnormalities of purine metabolism on the lymphocytes were studied. When the lymphocytes from the patients with Lesch-Nyhan syndrome in which HGPRT is defective were analysed. Immunoglobulin production from B-cells, mitotic response of T-cells, functions of helper T-cells and suppressor T-cells were thought to be impared. Killer T-cell function was seemed not very much affected. ADA deficiency produced by treating the lymphocytes with coformycin which specifically blocks the enzyme caused defective mitotic T-cell response and decreased immunoglobulin production from B-cells. Killer T-cell and K-cell functions showed only few impairment.
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