Abstract
An antineoplastic factor inducing tumor lysis was purified to apparent homogeneity from the supernatant of a homogenate of eggs of the sea hare Aplysia kwodai. On gel filtration, the purified substance gave a single band of material of 250 kDa containing 3 different subunits and this band coincided with cytolytic activity. The purified factor was half-maximally active at 10–60 ng protein/ml and lysed all tumor cells tested, but not normal cells. Antineoplastic factor Tumor lysis Sea hare Aplysia Cytolysis
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